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HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release
- 1.0346325 - ÚMCH 2011 RIV US eng J - Journal Article
Etrych, Tomáš - Šírová, Milada - Starovoytova, Larisa - Říhová, Blanka - Ulbrich, Karel
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release.
Molecular Pharmaceutics. Roč. 7, č. 4 (2010), s. 1015-1026. ISSN 1543-8384. E-ISSN 1543-8392
R&D Projects: GA MŠMT 1M0505; GA AV ČR IAAX00500803
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Keywords : N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer * docetaxel * paclitaxel
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.400, year: 2010
In this paper we describe the synthesis, physicochemical characteristics and data on the biological activity of polymer prodrugs based on the anticancer drugs paclitaxel (PTX) and docetaxel (DTX) conjugated with a water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer drug carrier. The drugs were derivatized and then attached to the polymer backbone via a spacer that is stable under physiological conditions (pH 7.4) and hydrolytically degradable in mild acidic environments (e.g., endosomes, pH similar to 5).
Permanent Link: http://hdl.handle.net/11104/0005970
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