Number of the records: 1  

The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability

  1. 1.
    0346290 - ÚOCHB 2011 RIV CZ eng J - Journal Article
    Elbert, Tomáš - Břehová, Petra - Holý, Antonín
    The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability.
    Collection of Czechoslovak Chemical Communications. Roč. 75, č. 7 (2010), s. 757-766. ISSN 0010-0765
    R&D Projects: GA MŠMT 1M0508; GA AV ČR IAA400550801
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : tritium * 3-H NMR * acyclic nucleotide analogues
    Subject RIV: CC - Organic Chemistry
    Impact factor: 0.853, year: 2010

    9-(2-Phosphonomethoxyethyl)-2,6-diamino-[8-3H]purine, 9-(2-phosphonomethoxyethyl)- [8-3H]guanine and (R)- 9-(2-phosphonomethoxypropyl)-[8-3H]adenine with specific activities of 10.9 Ci/mmol, 7.9 Ci/mmol and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds with the hydrogen of water under physiological pH at 20 °C was studied using 3H NMR.
    Permanent Link: http://hdl.handle.net/11104/0187358

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.