Comparison of the Effects of Possible Mechanical Stimuli on the Rate of Biochemical Reactions

0346212 - ÚT 2011 RIV US eng J - Journal Article
Klika, Václav
Comparison of the Effects of Possible Mechanical Stimuli on the Rate of Biochemical Reactions.
Journal of Physical Chemistry B. Roč. 114, č. 32 (2010), s. 10567-10572. ISSN 1520-6106. E-ISSN 1520-5207
R&D Projects: GA ČR(CZ) GA106/08/0557
Institutional research plan: CEZ:AV0Z20760514
Keywords : coupling * curie principle * nonequilibrium thermodynamics
Subject RIV: BJ - Thermodynamics
Impact factor: 3.603, year: 2010
http://pubs.acs.org/doi/abs/10.1021/jp1000072

The aim of this work is to address the question of what constitutes a mechanical stimulation of biochemical reactions in general and further to compare the importance of the two possible mechanical stimulations: shear rate and the rate of volume variation. Using linear nonequilibrium thermodynamics, the Curie principle (the relation for coupling phenomena) is retrieved for a phenomenological relation for a scalar flux in an isotropic system. From these phenomenological relations for the rate of chemical reaction, it is established that the only scalar quantity related to the rate of deformation tensor that cannot be neglected is the rate of volume variation. This leads us to the conclusion that the volume variation rate is the most important mechanical stimulus driving the processes in them.
Permanent Link: http://hdl.handle.net/11104/0005965