Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

0345886 - ÚOCHB 2011 RIV NL eng J - Journal Article
Keough, D. T. - Hocková, Dana - Krečmerová, Marcela - Česnek, Michal - Holý, Antonín - Naesens, L. - Brereton, I. M. - Winzor, D. J. - de Jersey, J. - Guddat, L. W.
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy.
Molecular and Biochemical Parasitology. Roč. 173, č. 2 (2010), s. 165-169. ISSN 0166-6851. E-ISSN 1872-9428
R&D Projects: GA MŠMT 1M0508
Grant - others:National Health and Medical Research Council(AU) 569703
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * Plasmodium vivax * 6-oxopurine phosphoribosyltransferase
Subject RIV: CC - Organic Chemistry
Impact factor: 2.875, year: 2010

For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M.
Permanent Link: http://hdl.handle.net/11104/0187064