Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension

0345854 - FGÚ 2011 RIV US eng J - Journal Article
Líšková, Silvia - Petrová, M. - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension.
Journal of the American Society of Hypertension. Roč. 4, č. 3 (2010), s. 128-134. ISSN 1933-1711
R&D Projects: GA AV ČR(CZ) IAA500110902
Institutional research plan: CEZ:AV0Z50110509
Keywords : potassium channels * nitric oxide * norepinephrine
Subject RIV: ED - Physiology
Impact factor: 0.931, year: 2010

The activation of Ca2+-dependent K+ channels (BKCa) leads to the attenuation of vascular contraction. Our study aimed to evaluate BKCa influence on norepinephrine (NE)-induced femoral artery contraction in two forms of genetic hypertension. NO-dependent attenuation of NE-induced contractions was greater in SHR than HTG or Wistar vessels, whereas large conductance Ca2+-dependent K+ channels may play a greater role in modulating vascular contraction in the severe form of hypertension
Permanent Link: http://hdl.handle.net/11104/0187038