Number of the records: 1
Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia
- 1.0345750 - FGÚ 2011 RIV US eng J - Journal Article
Smolková, Katarína - Bellance, N. - Scandurra, F. - Génot, E. - Gnaiger, E. - Plecitá-Hlavatá, Lydie - Ježek, Petr - Rossignol, R.
Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia.
Journal of Bioenergetics and Biomembranes. Roč. 42, č. 1 (2010), s. 55-67. ISSN 0145-479X. E-ISSN 1573-6881
R&D Projects: GA AV ČR(CZ) IAA500110701
Institutional research plan: CEZ:AV0Z50110509
Keywords : mitochondria * oxidative phosphorylation * breast cancer
Subject RIV: CE - Biochemistry
Impact factor: 3.637, year: 2010
Breasts cancer cells can survive and proliferate under harsh conditions of nutrient deprivation, including limited oxygen and glucose availability. Here, we mimicked aglycemia and hypoxia in vitro and compared the mitochondrial and cellular bioenergetic adaptation of human breast cancer (HTB-126) and non-cancer (HTB-125) cells that originate from breast tissue. The data demonstrate that cancer cells behave differently than normal cells when adapting their bioenergetics to microenviromental conditions
Permanent Link: http://hdl.handle.net/11104/0186950
Number of the records: 1