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Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor
- 1.0345749 - ÚJF 2011 RIV GB eng J - Journal Article
Štísová, Viktorie - Goffinont, S. - Maurizot, M. S. - Davídková, Marie
Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor.
Radiation Physics and Chemistry. Roč. 79, č. 8 (2010), s. 880-889. ISSN 0969-806X. E-ISSN 1879-0895
R&D Projects: GA MŠMT 1P05OC085; GA MŠMT OC09012
Institutional research plan: CEZ:AV0Z10480505
Keywords : DNA-protein complex * estrogen response element * estrogen receptor * ionizing radiation
Subject RIV: BO - Biophysics
Impact factor: 1.132, year: 2010
The radiosensitivity in vitro of the complex between ER alpha, a subtype of this receptor, and a DNA fragment bearing ERE, as well as the influence of an estrogen (estradiol) or an anti-estrogen (tamoxifen) on this radiosensitivity were studied. We observed that the complex is destabilized upon irradiation with gamma rays in aerated aqueous solution.
Permanent Link: http://hdl.handle.net/11104/0186949
Number of the records: 1