Number of the records: 1
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors
- 1.0345730 - ÚOCHB 2011 RIV GB eng J - Journal Article
Šála, Michal - De Palma, A. M. - Hřebabecký, Hubert - Nencka, Radim - Dračínský, Martin - Leyssen, P. - Neyts, J. - Holý, Antonín
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.
Bioorganic & Medicinal Chemistry. Roč. 18, č. 12 (2010), s. 4374-4384. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : 6-chloropurine * coxsackievirus B3 * bicyclo[2.2.1]heptane
Subject RIV: CC - Organic Chemistry
Impact factor: 2.978, year: 2010
Novel class of coxsackievirus inhibitors derived from a bicyclo[2.2.1]heptane was synthetised and target compounds were tested for antiviral activity against coxsackievirus B3. Most analogues showed activity in the low micromolar range with minimal cytotoxicity.
Permanent Link: http://hdl.handle.net/11104/0186933
Number of the records: 1