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Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles
- 1.0345370 - BFÚ 2011 RIV US eng J - Journal Article
Zerzánková, Lenka - Suchánková, T. - Vrána, Oldřich - Farrell, N.P. - Brabec, Viktor
Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
Biochemical Pharmacology. Roč. 79, č. 2 (2010), s. 112-121. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MŠMT(CZ) LC06030; GA MŠMT(CZ) ME08017; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651
Grant - others:GA MŠk(CZ) OC09018
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : antitumor * dinuclear platinum complex * DNA damage
Subject RIV: BO - Biophysics
Impact factor: 4.889, year: 2010
A detailed biochemical and molecular biophysics study of the molecular mechanism of action of a new dinuclear PtII complex [{PtCl(1,2-diaminocyclohexane)}2-my-Y]4+, resistant to decomposition by sulfur nucleophiles, was reported herein. The results show that this complex exhibits promising antitumor features as its DNA adducts can largely escape repair and inhibit very effectively transcription.
Permanent Link: http://hdl.handle.net/11104/0186655
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