Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells

0345305 - BFÚ 2011 RIV NL eng J - Journal Article
Valovičová, Z. - Marvanová, S. - Mészárosová, M. - Srančíková, A. - Trilecová, L. - Milcová, A. - Líbalová, H. - Vondráček, Jan - Machala, M. - Topinka, J. - Gábelová, A.
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 665, 1-2 (2009), s. 51-60. ISSN 0027-5107
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : DNA adducts * DNA strand breaks * oxidative stress
Subject RIV: BO - Biophysics
Impact factor: 3.556, year: 2009

In the present study we demonstrated qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 liver cells. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC derivative.
Permanent Link: http://hdl.handle.net/11104/0186613