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A potent cytotoxic photoactivated platinum complex
- 1.0345270 - BFÚ 2011 RIV US eng J - Journal Article
Mackay, F.S. - Woods, J.A. - Heringová, Pavla - Kašpárková, Jana - Pizarro, A.M. - Moggach, S.A. - Parsons, S. - Brabec, Viktor - Sadler, P.J.
A potent cytotoxic photoactivated platinum complex.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 104, č. 52 (2007), s. 20743-20748. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR(CZ) GA305/05/2030; GA ČR(CZ) GD204/03/H016; GA MZd(CZ) NR8562; GA AV ČR(CZ) 1QS500040581
Grant - others:GA AV ČR(CZ) KAN200200651
Program: KA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : cytotoxicity * DNA binding * photochemistry
Subject RIV: BO - Biophysics
Impact factor: 9.598, year: 2007
Platinum(IV)diazido complexes containing cis-diam(m)ine ligands are relatively inert in the dark. We report here the dramatic effects arising from incorporation of a pyridine ligand in place of an ammine ligand. trans,trans,trans-[Pt(N3)2(OH)2(NH3)(py)] is highly phototoxic and reacts with guanine derivatives and with DNA to give unusual PtII adducts not readily formed in the absence of light.
Permanent Link: http://hdl.handle.net/11104/0186584
Number of the records: 1