The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance

0345074 - FGÚ 2011 RIV US eng J - Journal Article
Atanur, S. S. - Birol, I. - Guryev, V. - Hirst, M. - Hummel, O. - Morrissey, C. - Behmoaras, J. - Fernandez-Suarez, X.M. - Johnson, M. D. - McLaren, W. M. - Patone, G. - Petretto, E. - Plessy, Ch. - Rockland, K. S. - Rockland, Ch. - Saar, K. - Zhao, Y. - Carninci, P. - Flicek, P. - Kurtz, T. - Cuppen, E. - Pravenec, Michal - Hubner, N. - Jones, S. J. M. - Birney, E. - Aitman, T. J.
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
Genome Research. Roč. 20, č. 6 (2010), s. 791-803. ISSN 1088-9051. E-ISSN 1549-5469
R&D Projects: GA MŠMT(CZ) 1M0520
Grant - others:EC(XE) LSHG-CT-2005-019015; HHMI(US) HHMI; Transatlantic network of excellence(US) Foundation Leducq
Institutional research plan: CEZ:AV0Z50110509
Keywords : spontaneously hypertensive rat * genome sequence * genetics
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 13.588, year: 2010

The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. Scores of SHR quantitative loci (QTLs) have been mapped for hypertension and other phenotypes. We have sequenced the SHR/OlaIpcv genome at 10.7-fold coverage by paired-end sequencing on the Illumina platform. This near complete catalog of genomic differences between two extensively studied rat strains provides the starting point for complete elucidation, at the molecular level, of the physiological and pathophysiological phenotypic differences between individuals from these strains
Permanent Link: http://hdl.handle.net/11104/0186428