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Growth of Vascular Smooth Muscle Cells on Collagen I Exposed to RBL-2H3 Mastocytoma Cells
- 1.0345062 - FGÚ 2011 RIV CH eng J - Journal Article
Maxová, H. - Bačáková, Lucie - Eckhardt, Adam - Mikšík, Ivan - Lisá, Věra - Novotná, J. - Herget, J.
Growth of Vascular Smooth Muscle Cells on Collagen I Exposed to RBL-2H3 Mastocytoma Cells.
Cellular Physiology and Biochemistry. Roč. 25, č. 6 (2010), s. 615-622. ISSN 1015-8987
R&D Projects: GA ČR(CZ) GA305/08/0108; GA MŠMT(CZ) 1M0510
Institutional research plan: CEZ:AV0Z50110509
Keywords : pulmonary hypertension * collagen degradation * smooth muscle cell proliferation
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 3.585, year: 2010
The aim of this “in vitro” study was to verify that mast cells are capable of splitting collagen and then facilitating the growth of vascular smooth muscle cells (VSMC). Increased growth activity of VSMC was probably due to the fragmentation of collagen by proteases released from RBL-2H3 cells. Mast cells exposed to hypoxia are more capable to split collagen and facilitate the gowth of VSMC
Permanent Link: http://hdl.handle.net/11104/0186424
Number of the records: 1