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High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro
- 1.0345018 - ÚI 2011 RIV US eng J - Journal Article
Jiruška, P. - Csicsvari, J. - Powell, A.V. - Fox, J.E. - Chang, W.C. - Vreugdenhil, M. - Li, X. - Paluš, Milan - Bujan, A.F. - Dearden, R.W. - Jefferys, J. G. R.
High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro.
Journal of Neuroscience. Roč. 30, č. 16 (2010), s. 5690-5701. ISSN 0270-6474. E-ISSN 1529-2401
Institutional research plan: CEZ:AV0Z10300504
Keywords : mammalian hippocampus invitro * temporal-lobe epilepsy * nonsynaptic epileptogenesis * spatiotemporal dynamics * after-discharges * pyramidal cells * oscillations * rat * calcium * slice
Subject RIV: FH - Neurology
Impact factor: 7.271, year: 2010
How seizures start is a major question in epilepsy research. We demonstrate the existence of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) and reduction in system complexity. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure.
Permanent Link: http://hdl.handle.net/11104/0186396
Number of the records: 1