Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat

0344049 - FGÚ 2011 RIV GB eng J - Journal Article
Jirout, M. L. - Friese, R. S. - Mahapatra, N. R. - Mahata, M. - Taupenot, L. - Mahata, S. K. - Křen, V. - Zídek, Václav - Fischer, J. - Maatz, H. - Ziegler, M. G. - Pravenec, Michal - Hubner, N. - Aitman, T. J. - Schork, N. J. - O´Connor, D. T.
Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.
Human Molecular Genetics. Roč. 19, č. 13 (2010), s. 2567-2580. ISSN 0964-6906. E-ISSN 1460-2083
R&D Projects: GA AV ČR(CZ) IAA500110604
Grant - others:HHMI(US) HHMI
Institutional research plan: CEZ:AV0Z50110509
Keywords : spontaneously hypertensive rat * catecholamines * blood pressure
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.058, year: 2010

We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. We also detected trans-regulated expression of Vmat1 and Chga (both involved in catecholamine storage), with co-localization of these trans-eQTLs to the Pnmt locus. The finding of such cis- and trans-QTLs at an age before the onset of frank hypertension suggests that these heritable changes in biosynthetic enzyme expression represent primary genetic mechanisms for regulation of catecholamine action and blood pressure control in this widely studied model of hypertension
Permanent Link: http://hdl.handle.net/11104/0186368