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The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801
- 1.0344048 - FGÚ 2011 RIV NL eng J - Journal Article
Valeš, Karel - Svoboda, Jan - Benkovičová, Kristína - Bubeníková-Valešová, V. - Stuchlík, Aleš
The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801.
European Journal of Pharmacology. Roč. 639, 1-3 (2010), s. 91-98. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA MZd(CZ) NR9178
Institutional research plan: CEZ:AV0Z50110509
Keywords : animal model of schizophrenia * metabotropic glutamate receptor * cognition
Subject RIV: FH - Neurology
Impact factor: 2.737, year: 2010
The manipulation of glutamate neurotransmission could represent a potential strategy for the pharmacotherapy of schizophrenic symptoms. In our study we evaluated the effect of agonists and allosteric modulators of mGluR2/3 and mGluR5 on performance in a cognitive task in animal model of schizophrenia like behavior. The results show that application of the mGlu2/3 receptor agonist had no effect on cognitive impairment. However, the mGlu5 receptor agonists ameliorated cognitive impairment without affecting locomotion
Permanent Link: http://hdl.handle.net/11104/0186367
Number of the records: 1