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Local metabolism of glucocorticoids and its role in rat adjuvant arthritis
- 1.0344044 - FGÚ 2011 RIV IE eng J - Journal Article
Ergang, Peter - Leden, P. - Vagnerová, Karla - Klusoňová, Petra - Mikšík, Ivan - Jurčovičová, J. - Kment, M. - Pácha, Jiří
Local metabolism of glucocorticoids and its role in rat adjuvant arthritis.
Molecular and Cellular Endocrinology. Roč. 323, č. 2 (2010), s. 155-160. ISSN 0303-7207. E-ISSN 1872-8057
R&D Projects: GA ČR(CZ) GA305/07/0328
Grant - others:Univerzita Karlova(CZ) UK 77/2006C
Institutional research plan: CEZ:AV0Z50110509
Keywords : 11beta-hydroxysteroid dehydrogenase * arthritis * Lewis rats
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 4.119, year: 2010
The study demonstrates that arthritis upregulates synovial 11beta-hydroxysteroid dehydrogenase, this upregulation is controlled by TNF-alpha and IL-1beta and that the increased supply of local corticosterone might contribute to feedback regulation of inflammation
Permanent Link: http://hdl.handle.net/11104/0186364
Number of the records: 1