High-LET Radiation-Induced Response of Microvessels in the Hippocampus

0344033 - FGÚ 2011 RIV US eng J - Journal Article
Mao, X. W. - Favre, C. J. - Fike, J. R. - Kubínová, Lucie - Anderson, E. - Campbell-Beachler, M. - Jones, T. - Smith, A. - Rightnar, S. - Nelson, G. A.
High-LET Radiation-Induced Response of Microvessels in the Hippocampus.
Radiation Research. Roč. 173, č. 4 (2010), s. 486-493. ISSN 0033-7587. E-ISSN 1938-5404
Institutional research plan: CEZ:AV0Z50110509
Keywords : hippocampus * stereology * microvessels
Subject RIV: EA - Cell Biology
Impact factor: 2.578, year: 2010

Endothelial population changes in hippocampal microvessels exposed to 56Fe ions at doses of 0, 0.5, 2 and 4 Gy were quantified using unbiased stereological techniques. Twelve months after exposure, mice that received 0.5 Gy or 2 Gy of iron ions showed a 34% or 29% loss of endothelial cells, respectively, in the hippocampal cornu ammonis region 1 (CA1) compared to age-matched controls or mice that received 4 Gy. In contrast to the CA1, in the dentate gyrus (DG), there was no significant difference in microvessel cell and length density between irradiated groups and age-matched controls. Vascular topology differences between CA1 and DG may account for the variation in dose response
Permanent Link: http://hdl.handle.net/11104/0186356