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beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics

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    0344010 - ÚEB 2011 RIV US eng J - Journal Article
    Amigues, E.J. - Armstrong, E. - Dvořáková, Marcela - Migaud, M.E. - Huang, M.
    beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics.
    Nucleosides Nucleotides & Nucleic Acids. Roč. 28, č. 3 (2009), s. 238-259. ISSN 1525-7770. E-ISSN 1532-2335
    Institutional research plan: CEZ:AV0Z50380511
    Keywords : Nucleoside * nucleotide * sirtuin
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 0.768, year: 2009

    The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
    Permanent Link: http://hdl.handle.net/11104/0186347

     
     
Number of the records: 1  

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