Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy

0343927 - ÚMCH 2011 RIV GB eng J - Journal Article
Lammers, T. - Šubr, Vladimír - Ulbrich, Karel - Hennink, W. E. - Storm, G. - Kiessling, F.
Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy.
Nano Today. Roč. 5, č. 3 (2010), s. 197-212. ISSN 1748-0132. E-ISSN 1878-044X
R&D Projects: GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z40500505
Keywords : nanomedicines * drug targeting * polymer
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 11.750, year: 2010

Nanomedicine systems aim to improve the biodistribution and the target site accumulation of systemically applied (chemo-) therapeutics. By increasing drug localization at the pathological site, and by reducing its accumulation in healthy organs and tissues, the efficacy of the intervention can often be increased, while its toxicity can be attenuated. Using HPMA copolymers as a model macromolecular nanomedicine system, and several selected examples of recently published proof-of-principle reports, we here show that besides for standard drug delivery purposes, polymeric nanomedicines can also be employed for image-guided drug delivery, as well as for tumor-targeted combination therapy.
Permanent Link: http://hdl.handle.net/11104/0186287