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The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry
- 1.0343810 - BFÚ 2011 RIV CZ eng J - Journal Article
Vacek, J. - Havran, Luděk - Fojta, Miroslav
The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry.
Collection of Czechoslovak Chemical Communications. Roč. 74, 11-12 (2009), s. 1727-1738. ISSN 0010-0765
R&D Projects: GA ČR(CZ) GA203/07/1195; GA MŠMT(CZ) LC06035; GA AV ČR(CZ) 1QS500040581
Grant - others:GA AV ČR(CZ) IAA400040903
Program: IA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : doxorubicin * mercury electrode * chronopotentiometry
Subject RIV: BO - Biophysics
Impact factor: 0.856, year: 2009
Voltammetry with linear scan and chronopotentiometric stripping (CPS) with constant current were used for the analysis of doxorubicin (DOX) at the hanging mercury drop electrode. CPS was used for the study of DOX in situ electrochemical reduction in adsorbed state and for ex situ (adsorptive transfer) analysis of the drug. The CPS method was also applied to monitor the DOX interaction with double- and single-stranded DNA.
Permanent Link: http://hdl.handle.net/11104/0186199
Number of the records: 1