Electrochemistry of selected radiosenzitizer-etanidazole

0343502 - ÚFCH JH 2011 RIV CZ eng C - Conference Paper (international conference)
Gál, Miroslav - Híveš, J. - Sokolová, Romana - Hromadová, Magdaléna - Kocábová, Jana - Kolivoška, Viliam - Pospíšil, Lubomír
Electrochemistry of selected radiosenzitizer-etanidazole.
Sborník přednášek. XXX. Moderní elektroanalytické metody. Ústí nad Labem: BEST servis, 2010 - (Navrátil, T.; Barek, J.), s. 55-59. ISBN 978-80-254-6710-7.
[Modern Electroanalytical Methods /30./. Jetřichovice (CZ), 24.05.2010-28.05.2010]
R&D Projects: GA ČR GP203/09/P502; GA MŠMT LC510; GA MŠMT OC 140
Institutional research plan: CEZ:AV0Z40400503
Keywords : etanidazole * cyclic voltammetry * radiosensitizers * electrochemical impendance spectroscopy
Subject RIV: CG - Electrochemistry

The first electron transfer to radiosensitizer etanidazole (ETN) and ETN radical anion formation in buffered aqueous media was studied by means of voltammetric techniques and Electrochemical Impendance Spectroscopy (EIS). The heterogeneous electron transfer rate constant for the first reduction of ETN (radical anion production) k0 for the redox couple and so called E1,7 potential were calculated. The obtained values of k0 and E1,7 potential indicate that ETN compared to some other possible chemical radiosensitizers requires lower energy to accept the first electron during metabolic pathway.
Permanent Link: http://hdl.handle.net/11104/0185965