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Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids

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    0343394 - ÚOCHB 2011 RIV DE eng J - Journal Article
    Hocková, Dana - Dračínský, Martin - Holý, Antonín
    Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids.
    European Journal of Organic Chemistry. -, č. 15 (2010), s. 2885-2892. ISSN 1434-193X. E-ISSN 1099-0690
    R&D Projects: GA MŠMT 1M0508
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : nucleotides * phosphonates * cross-coupling
    Subject RIV: CC - Organic Chemistry
    Impact factor: 3.206, year: 2010

    A series of novel acyclic nucleoside phosphonates with a built-in arylphosphonate moiety has been prepared by a microwave-assisted cross-coupling reaction as the key step. Their cytostatic and antiviral activities were tested. The pKa values of the target ortho-, meta- and para-substituted arylphosphonates were determined by 31P NMR titration studies.
    Permanent Link: http://hdl.handle.net/11104/0185885

     
     
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