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Preparation of new 18alpha-oleanane alcohols: synthesis, characterization, and cytotoxic activity

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    0343366 - ÚOCHB 2011 RIV AT eng J - Journal Article
    Kvasnica, Miroslav - Rudovská, I. - Hajduch, M. - Šarek, J.
    Preparation of new 18alpha-oleanane alcohols: synthesis, characterization, and cytotoxic activity.
    Monatshefte fur Chemie. Roč. 141, č. 2 (2010), s. 233-244. ISSN 0026-9247. E-ISSN 1434-4475
    R&D Projects: GA AV ČR KAN200200651
    Grant - others:GA ČR(CZ) GP203/05/P025; GA ČR(CZ) GA305/09/1216
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : reduction * hydride * ketone * configuration * cytotoxicity
    Subject RIV: CC - Organic Chemistry
    Impact factor: 1.356, year: 2010

    New oleanane alcohols and their acetates were prepared using classical reductive reagents (LiA1H4, NaBH4, and B2H6-DMS). These products were tested for cytotoxic activity against T-lymphoblastic leukemia (CEM), human erythromyeloblastoid leukemia (K562), and human melanoma (SK-MEL1) cell lines.
    Permanent Link: http://hdl.handle.net/11104/0005912

     
     
Number of the records: 1  

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