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The interactions of the C-terminal region of the TRPC6 channel with calmodulin
- 1.0343356 - FGÚ 2011 RIV GB eng J - Journal Article
Friedlová, Eliška - Gryčová, Lenka - Holakovská, Blanka - Šilhán, Jan - Janoušková, Hana - Šulc, Miroslav - Obšilová, Veronika - Obšil, T. - Teisinger, Jan
The interactions of the C-terminal region of the TRPC6 channel with calmodulin.
Neurochemistry International. Roč. 56, č. 2 (2010), s. 363-366. ISSN 0197-0186. E-ISSN 1872-9754
R&D Projects: GA AV ČR(CZ) IAA600110701; GA ČR(CZ) GA303/07/0915; GA ČR(CZ) GD305/08/H037; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z50200510
Keywords : TRPC6 * calmodulin * fluorescence anisotropy
Subject RIV: BO - Biophysics
Impact factor: 3.601, year: 2010
TRPC6 is a non-selective cation channel which modulates the calcium level in eukaryotic cells in response to external signals. One calmodulin (CaM) binding site was identified within the C-tail of TRPC6. The aim of this study is to map in detail the CaM and inositol (1,4,5)-triphosphate receptor binding (CIRB) domain in the C-terminal region of mouse TRPC6 that is capable of interacting with CaM using in vitro binding assays
Permanent Link: http://hdl.handle.net/11104/0185855
Number of the records: 1