Dependence of Multidrug Resistance Protein-Mediated Cyclic Nucleotide Efflux on the Background Sodium Conductance

0343224 - FGÚ 2011 RIV US eng J - Journal Article
Kučka, M. - Kretschmannová, K. - Murano, T. - Wu, Ch. P. - Zemková, Hana - Ambudkar, S. V. - Stojilkovic, S. S.
Dependence of Multidrug Resistance Protein-Mediated Cyclic Nucleotide Efflux on the Background Sodium Conductance.
Molecular Pharmacology. Roč. 77, č. 2 (2010), s. 270-279. ISSN 0026-895X. E-ISSN 1521-0111
Institutional research plan: CEZ:AV0Z50110509
Keywords : multidrug resistance protein * cAMP * anterior pituitary
Subject RIV: ED - Physiology
Impact factor: 4.725, year: 2010

Anterior pituitary cells fire action potentials and release cyclic nucleotides both spontaneously and in response to agonist stimulation. A tetrodotoxin-resistant background Na+ conductance is critical for firing of these action potentials. In these cells, multidrug resistance proteins MRP4 and MRP5 -mediated cyclic nucleotide efflux can be rapidly determined by the background Na+ conductance
Permanent Link: http://hdl.handle.net/11104/0185748