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Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment

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    0343142 - ÚT 2011 RIV NL eng J - Journal Article
    Maršík, František - Klika, Václav - Chlup, Hynek
    Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment.
    Mathematics and Computers in Simulation. Roč. 80, č. 6 (2010), s. 1278-1288. ISSN 0378-4754. E-ISSN 1872-7166
    R&D Projects: GA ČR GA106/03/1073; GA ČR(CZ) GA106/08/0557
    Grant - others:GA ČR(CZ) GA201/06/0352
    Institutional research plan: CEZ:AV0Z20760514
    Keywords : bone remodelling * chemical kinetics * biochemical model
    Subject RIV: BJ - Thermodynamics
    Impact factor: 0.812, year: 2010
    http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6V0T-4VT1FYX-1-1&_cdi=5655&_user=640952&_pii=S0378475409000664&_origin=search&_coverDate=02%2F28%2F2010&_sk=999199993&view=c&wchp=dGLzVlz-zSkzV&md5=efaf801defe31154a1c6c44a9c5edef0&ie=/sdarticle.pdf

    The biomechanical remodelling process is well formulated for bones and is divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway-RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the omogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated.
    Permanent Link: http://hdl.handle.net/11104/0185684

     
     
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