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Charge transport in DNA oligonucleotides with various base-pairing patterns

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    0342650 - FZÚ 2011 RIV US eng J - Journal Article
    Kratochvílová, Irena - Todorciuc, Tatiana - Král, Karel - Němec, Hynek - Bunček, M. - Šebera, Jakub - Záliš, Stanislav - Vokáčová, Zuzana - Sychrovský, Vladimír - Bednárová, Lucie - Mojzeš, P. - Schneider, Bohdan
    Charge transport in DNA oligonucleotides with various base-pairing patterns.
    Journal of Physical Chemistry B. Roč. 114, č. 15 (2010), 5196–5205. ISSN 1520-6106. E-ISSN 1520-5207
    R&D Projects: GA ČR GA203/08/1594; GA AV ČR KAN401770651; GA MŠMT OC 137; GA ČR GA202/07/0643; GA AV ČR IAA400550701; GA AV ČR KAN200100801; GA AV ČR KAN100400702; GA ČR GA202/09/0193
    Institutional research plan: CEZ:AV0Z10100520; CEZ:AV0Z40500505; CEZ:AV0Z40400503; CEZ:AV0Z40550506; CEZ:AV0Z50520701
    Keywords : DNA * charge transport * Scanning Tunneling Microscopy
    Subject RIV: CC - Organic Chemistry
    Impact factor: 3.603, year: 2010

    We combined various experimental (STM, Raman spectroscopy) and theoretical (DFT, MD) approaches to study the relationships between the base-pairing patterns and charge transfer properties in DNA 32-mer duplexes that may be relevant for identification and repair of defects in base pairing of the genetic DNA and for DNA use in nanotechnologies. Studied were two duplexes fully Watson-Crick paired, one mismatched (containing three non-W-C pairs), and three with base pairs chemically removed. The results show that the charge transport varies strongly between these duplexes. The conductivity of the mismatched duplex is considerably lower than that of the W-C-paired one despite that their structural integrity and thermal stability are comparable. Structurally and thermally much less stable abasic duplexes have still lower conductivity, but not markedly different from the mismatched duplex.
    Permanent Link: http://hdl.handle.net/11104/0005881

     
     
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