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Determination of the level of DNA modification with cisplatin by catalytic hydrogen evolution at mercury-based electrodes
- 1.0342607 - BFÚ 2011 RIV US eng J - Journal Article
Horáková Brázdilová, Petra - Těsnohlídková, Lucie - Havran, Luděk - Vidláková, Pavlína - Pivoňková, Hana - Fojta, Miroslav
Determination of the level of DNA modification with cisplatin by catalytic hydrogen evolution at mercury-based electrodes.
Analytical Chemistry. Roč. 82, č. 7 (2010), s. 2969-2976. ISSN 0003-2700. E-ISSN 1520-6882
R&D Projects: GA ČR(CZ) GP204/07/P476; GA AV ČR(CZ) IAA500040701; GA AV ČR(CZ) 1QS500040581; GA MŠMT(CZ) LC06035
Grant - others:GA AV ČR(CZ) IAA400040903
Program: IA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : cisplatin * electrochemical analysis of DNA * mercury electrode
Subject RIV: BO - Biophysics
Impact factor: 5.874, year: 2010
In this paper we used voltammetry at the mercury-based electrodes for the monitoring of DNA modification with cisdiamminedichloroplatinum (cisplatin), a representative of metallodrugs used in the treatment of various types of cancer or being developed for such purpose. Application of the electrochemical technique in studies of DNA reactivity with various anticancer platinum compounds, as well as for an easy determination of the extent of DNA platination in studies of its biochemical effects, is discussed.
Permanent Link: http://hdl.handle.net/11104/0185298
Number of the records: 1