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Estradiol Supplementation Helps Overcome Central Leptin Resistance of Ovariectomized Mice on a High Fat Diet

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    0342535 - ÚOCHB 2011 RIV DE eng J - Journal Article
    Matyšková, Resha - Železná, Blanka - Maixnerová, Jana - Koutová, Darja - Haluzík, M. - Maletínská, Lenka
    Estradiol Supplementation Helps Overcome Central Leptin Resistance of Ovariectomized Mice on a High Fat Diet.
    Hormone and Metabolic Research. Roč. 42, č. 3 (2010), s. 182-186. ISSN 0018-5043. E-ISSN 1439-4286
    R&D Projects: GA ČR GA305/06/0427; GA ČR GA303/09/0744
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : leptin * estrogen deficiency * obesity
    Subject RIV: CE - Biochemistry
    Impact factor: 2.414, year: 2010

    Ovariectomized mice on a high fat diet represent a model of diet-induced obesity during estrogen deficiency. Ovariectomized mice on a high fat diet developed extreme obesity and hyperleptinemia and moderate hyperinsulinemia compared to those on a standard diet. The response to centrally injected leptin in ovariectomized mice on a high fat diet was insignificant, whereas in 17beta-estradiol-3-benzoate-supplemented mice, the effect was significant, particularly with respect to body weight.
    Permanent Link: http://hdl.handle.net/11104/0185248

     
     
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