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SUV39h- and Q1 A-type lamin-dependent telomere nuclear rearrangement
- 1.0342533 - BFÚ 2011 RIV US eng J - Journal Article
Uhlířová, Radka - Harničarová, Andrea - Galiová-Šustáčková, Gabriela - Legartová, Soňa - Matula, Pavel - Fojtová, Miloslava - Vařecha, M. - Amrichová, J. - Vondráček, Jan - Kozubek, Stanislav - Bártová, Eva
SUV39h- and Q1 A-type lamin-dependent telomere nuclear rearrangement.
Journal of Cellular Biochemistry. Roč. 109, č. 5 (2010), s. 915-926. ISSN 0730-2312. E-ISSN 1097-4644
R&D Projects: GA MŠMT ME 919
Grant - others:GA MŠk(CZ) LC06027; GA MŠk(CZ) LC535
Program: LC; LC
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : SUV39h * histone methyltransferases * telomeres
Subject RIV: BO - Biophysics
Impact factor: 3.122, year: 2010
We have observed that histone hyperacetylation cause changes in radial distribution of telomeres. In the cells with abrogated expression of SUV39h and LMNA genes, we observed changes in association between telomeres and PML bodies. This structural features represents an important marker of tumor cells. Our results showed that SUV39h and A-type lamins play an important role in nuclear architecture of telomeres.
Permanent Link: http://hdl.handle.net/11104/0185246
Number of the records: 1