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New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach
- 1.0342527 - FGÚ 2011 RIV US eng J - Journal Article
Petretto, E. - Bottolo, L. - Langley, S. R. - Heinig, M. - McDermott-Roe, Ch. - Sarwar, R. - Pravenec, Michal - Hübner, N. - Aitman, T. J. - Cook, S.A. - Richardson, S.
New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach.
PLoS Computational Biology. Roč. 6, č. 4 (2010), e1000737. ISSN 1553-734X. E-ISSN 1553-7358
R&D Projects: GA ČR(CZ) GA301/08/0166; GA MŠMT(CZ) 1M0520; GA ČR GAP301/10/0290
Grant - others:EC(XE) LSHG-CT-2005-019015; Fondation Leducq(FR) 06 CVD 03
Institutional research plan: CEZ:AV0Z50110509
Keywords : expression profiles * Bayesian multi-tissue approach * genetical genomics
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.515, year: 2010
To uncover complex genetic regulatory mechanisms controlling gene expression at the whole organism’s level, it is essential to develop appropriate analytical methods for the analysis of genome-wide genetic polymorphisms and gene expression profiles simultaneously in multiple tissues. This paper presents a novel, fully integrated Bayesian approach for mapping the genetic components of gene expression within and across multiple tissues
Permanent Link: http://hdl.handle.net/11104/0185241
Number of the records: 1