Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position

0342431 - ÚOCHB 2011 RIV GB eng J - Journal Article
Krečmerová, Marcela - Masojídková, Milena - Holý, Antonín
Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position.
Bioorganic & Medicinal Chemistry. Roč. 18, č. 1 (2010), s. 387-395. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : 5-azacytosine * acyclic nucleoside phosphonates * antivirals * orthoesters * condensation
Subject RIV: CC - Organic Chemistry
Impact factor: 2.978, year: 2010

A series of 6-alkyl derivatives of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (HPMP-5-azaC) was prepared using ammonia mediated ring-opening reaction of diisopropyl esters of HPMP-5-azaC to a corresponding carbamoylguanidine derivative followed by ring-closure reaction with orthoesters.
Permanent Link: http://hdl.handle.net/11104/0185170