Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency

0342427 - ÚOCHB 2011 RIV AT eng J - Journal Article
Hlaváček, Jan - Pícha, Jan - Vaněk, Václav - Jiráček, Jiří - Slaninová, Jiřina - Fučík, Vladimír - Buděšínský, Miloš - Gilner, D. - Holz, R. C.
Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency.
Amino Acids. Roč. 38, č. 4 (2010), s. 1155-1164. ISSN 0939-4451. E-ISSN 1438-2199
R&D Projects: GA AV ČR IAA400550614
Grant - others:NSF(US) CHE-0652981
Institutional research plan: CEZ:AV0Z40550506
Keywords : ArgE inhibitors * acetylornithine derivatives * synthesis * inhibitory and antiviral activity
Subject RIV: CC - Organic Chemistry
Impact factor: 4.106, year: 2010

A series of Nα-acyl(alkyl) and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase. N (alpha)-chloroacetyl-L-ornithine was the best inhibitor tested providing an IC50 value of 85 (mu)M.
Permanent Link: http://hdl.handle.net/11104/0185167