New coupling strategy for radionuclide labeling of synthetic polymers

0342352 - ÚMCH 2011 RIV GB eng J - Journal Article
Hrubý, Martin - Kučka, Jan - Nováková, Michaela - Macková, Hana - Vetrík, Miroslav
New coupling strategy for radionuclide labeling of synthetic polymers.
Applied Radiation and Isotopes. Roč. 68, č. 2 (2010), s. 334-339. ISSN 0969-8043
R&D Projects: GA AV ČR KAN200200651; GA ČR GA202/09/2078; GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z40500505
Keywords : polymer * radionuclide * labeling
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 0.999, year: 2010

We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
Permanent Link: http://hdl.handle.net/11104/0005864