Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 7: Methods of preparation and comparison of resulting physical properties

0342350 - ÚMCH 2011 RIV FR eng J - Journal Article
Přádný, Martin - Šlouf, Miroslav - Martinová, L. - Michálek, Jiří
Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 7: Methods of preparation and comparison of resulting physical properties.
E-Polymers. -, 043 (2010), s. 1-12. ISSN 1618-7229. E-ISSN 1618-7229
R&D Projects: GA ČR GA304/07/1129; GA ČR GA106/09/1000
Institutional research plan: CEZ:AV0Z40500505
Keywords : porous hydrogels * 2-hydroxyethyl methacrylate * porosity
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 0.574, year: 2010
http://www.e-polymers.org/journal/papers/mpradny_130410.pdf

Five methods of preparation of macroporous hydrogels are described and compared: precipitation polymerization, polymerization in presence of salt, polymerization in presence of gas-releasing compound, lyophilization and electrospinning. Crosslinked copolymers based on 2-hydroxyethyl methacrylate were selected as model hydrogels. Hydrogels were characterized by SEM microscopy, porosity, communicating/non-communicating pore ratio, pore sizes and their distributions. The advantages and drawbacks of the methods of preparation, modification of hydrogel properties, reproducibility and issues related to their preparation are discussed. The most convenient method was preparation in presence of salts. The use of prepared porous hydrogels is intended especially for scaffolds in tissue engineering.
Permanent Link: http://hdl.handle.net/11104/0005863