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Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate
- 1.0342344 - ÚOCHB 2011 RIV US eng J - Journal Article
Urban, M. - Joubert, Nicolas - Purse, B. W. - Hocek, Michal - Kuchta, R. D.
Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate.
Biochemistry. Roč. 49, č. 4 (2010), s. 727-735. ISSN 0006-2960
R&D Projects: GA MŠMT LC512; GA AV ČR IAA400550902
Grant - others:NIH(US) GM54194
Institutional research plan: CEZ:AV0Z40550506
Keywords : C-nucleosides * DNA polymerase * primase * mechanism
Subject RIV: CC - Organic Chemistry
Impact factor: 3.226, year: 2010
We used an extensive series of purine and pyrimidine nucleotide analogues to provide further insights into the mechanism by which primase chooses whether or not to polymerize a NTP. The data demonstrate that human primase strongly depends on Watson-Crick hydrogen bonds for efficient nucleotide polymerization.
Permanent Link: http://hdl.handle.net/11104/0185100
Number of the records: 1