Number of the records: 1
6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
- 1.0342338 - ÚOCHB 2011 RIV US eng J - Journal Article
Nauš, Petr - Pohl, Radek - Votruba, Ivan - Džubák, P. - Hajdúch, M. - Ameral, R. - Birkuš, G. - Wang, T. - Ray, A. S. - Mackman, R. - Cihlar, T. - Hocek, Michal
6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents.
Journal of Medicinal Chemistry. Roč. 53, č. 1 (2010), s. 460-470. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : nucleosides * 7-deazapurines * cross-coupling * cytostatic activity
Subject RIV: CC - Organic Chemistry
Impact factor: 5.207, year: 2010
A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies.
Permanent Link: http://hdl.handle.net/11104/0185095
Number of the records: 1