Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis

0341813 - FGÚ 2011 RIV US eng J - Journal Article
Malínská, H. - Oliyarnyk, O. - Hubová, M. - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Kazdová, L. - Kurtz, T. W. - Pravenec, Michal
Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.
Molecular and Cellular Biochemistry. Roč. 335, 1-2 (2010), s. 119-125. ISSN 0300-8177. E-ISSN 1573-4919
R&D Projects: GA AV ČR(CZ) IAA500110604; GA MZd(CZ) NR9387; GA MZd(CZ) NR9359
Grant - others:EC(XE) LSHG-CT-2005-019015
Institutional research plan: CEZ:AV0Z50110509
Keywords : hepatic steatosis * oxidative stress * fatty acid composition
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 2.168, year: 2010

Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.These results are consistent with the hypothesis that excess fat accumulation in the liver in association with increased oxidative stress and disturbances in the metabolism of saturated and unsaturated fatty acids may precede and contribute to the primary pathogenesis of NASH
Permanent Link: http://hdl.handle.net/11104/0184686