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Notes on the Asymmetric Hydrogenation of Methyl Acetoacetate in Neoteric Solvents
- 1.0341581 - ÚCHP 2011 RIV US eng J - Journal Article
Floriš, Tomáš - Klusoň, Petr - Muldoon, M. - Pelantová, Helena
Notes on the Asymmetric Hydrogenation of Methyl Acetoacetate in Neoteric Solvents.
Catalysis Letters. Roč. 134, 3-4 (2010), s. 279-287. ISSN 1011-372X. E-ISSN 1572-879X
R&D Projects: GA ČR(CZ) GD203/08/H032; GA AV ČR KAN400720701
Institutional research plan: CEZ:AV0Z40720504; CEZ:AV0Z50200510
Keywords : asymmetric hydrogenation * Ru-BINAP * ionic liquid
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 1.907, year: 2010
Asymmetric hydrogenation of methyl acetoacetate to methyl (R)-3-hydroxybutyrate by [(R)- RuCl(binap)(p-cymen)]Cl has been studied in methanol-ionic liquid and methanol- dense CO2 solvent systems. The ionic pairs triethylhexylammonium and 1-methylimidazolium with bis(trifluoromethane sulfonyl) imide and hexafluorophosphates were used. The role of ionic pairs on the kinetic parameters and (enantio)selectivity has been demonstrated. Although the CO2 expanded methanol system suffered from a reduction in both reaction rate and product selectivity, this changed in the presence of water.
Permanent Link: http://hdl.handle.net/11104/0184517
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