DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway

0341479 - MBÚ 2010 RIV GB eng J - Journal Article
Ullmannová-Benson, Veronika - Guan, M. - Zhou, X. G. - Tripathi, V. - Yang, V. - Zimonjic, D. B. - Popescu, C.
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
Leukemia. Roč. 23, č. 2 (2009), s. 383-390. ISSN 0887-6924. E-ISSN 1476-5551
Institutional research plan: CEZ:AV0Z50200510
Keywords : multiple myeloma * tumor suppressor gene * promoter methylation
Subject RIV: EC - Immunology
Impact factor: 8.296, year: 2009

DLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies because of epigenetic modifications or genomic deletion. Here, we identified DLC1 promoter hypermethylation in 43 out of 44 multiple myeloma (MM) cell lines, which resulted in downregulation or silencing of DLC1 in 41 samples
Permanent Link: http://hdl.handle.net/11104/0184459