CXC and CC chemokines induced in human renal epithelial cells by inflammatory cytokines

0341403 - MBÚ 2010 RIV US eng J - Journal Article
Thornburn, E. - Kolesar, L. - Brabcová, E. - Petříčková, Kateřina - Petříček, Miroslav - Jarešová, M. - Slavcev, A. - Stříž, I.
CXC and CC chemokines induced in human renal epithelial cells by inflammatory cytokines.
Acta Pathologica Microbiologica et Immunologica Scandinavica. Roč. 117, č. 7 (2009), s. 477-487. ISSN 0903-4641. E-ISSN 1600-0463
Institutional research plan: CEZ:AV0Z50200510
Keywords : Epithelial cells * chemokines * transplantation
Subject RIV: EE - Microbiology, Virology
Impact factor: 1.745, year: 2009

Human renal epithelial cells might play an important role during the allograft rejection by producing chemokines in response to proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta produced by endothelial and epithelial cells early after transplantation. The production of chemokines allows inflammatory cells to be drawn into the kidney graft and therefore plays a critical role in the pathophysiologic processes that lead to the rejection of renal transplant. In this process, two chemokine superfamilies, the CC and the CXC chemokines, are the most important
Permanent Link: http://hdl.handle.net/11104/0184404