Influence of Selenium on Innate Immune Response in Kids

0341165 - ÚŽFG 2010 RIV CZ eng J - Journal Article
Malá, D. - Kovářů, František - Mišurová, Ľ. - Pavlata, L. - Dvořák, R. - Číž, Milan
Influence of Selenium on Innate Immune Response in Kids.
Folia Microbiologica. Roč. 54, č. 6 (2009), s. 545-548. ISSN 0015-5632. E-ISSN 1874-9356
R&D Projects: GA AV ČR IAA601680801
Institutional research plan: CEZ:AV0Z50450515; CEZ:AV0Z50040702
Keywords : Se-75 labeled rats * Sodium selenite * Metabolism
Subject RIV: ED - Physiology
Impact factor: 0.978, year: 2009

The effect is described of selenium supplemented in an inorganic and organic form on the innate immune response of goats. Though the phagocytic activity (as a marker of the immune function) was found to be lower in organic-Se-treated group than in control (54.5 +/- 4.32 vs. 60.2 +/- 9.15 %), it did not generally exhibit any significant differences; similarly, no differences were found in the phagocytic index. The production of reactive oxygen species (ROS) was determined using the luminol-enhanced chemiluminescence (CL) (estimated as peak CL, integral CL and a peak time after addition of calcium ionophore A23187, opsonised zymosan (OZP) and phorbol-12-myristate-13-acetate as effectors. A significant ROS increase reflected in integral CL and a peak time was found in the inorganic-Se-treated group when OZP was used as activator; other parameters did not exhibit significant changes. The supplementation of Se in inorganic form can thus be seen to influence positively the innate immune system of kids.
Permanent Link: http://hdl.handle.net/11104/0184239