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Cell-Mediated Immunity in Cervical Cancer Evolution

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    0341159 - ÚFE 2010 RIV US eng J - Journal Article
    Jandová, Anna - Pokorný, Jiří - Kobilková, J. - Janoušek, M. - Mašata, J. - Trojan, S. - Nedbalová, M. - Dohnalová, A. - Beková, A. - Slavík, V. - Čoček, A. - Sanitrák, J.
    Cell-Mediated Immunity in Cervical Cancer Evolution.
    Electromagnetic Biology and Medicine. Roč. 28, č. 1 (2009), s. 1-14. ISSN 1536-8378. E-ISSN 1536-8386
    R&D Projects: GA MŠMT OC 288.001
    Institutional research plan: CEZ:AV0Z20670512
    Keywords : Biophysics * Cancer * Electromagnetic fields
    Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering
    Impact factor: 0.729, year: 2009

    Cell-mediated immunity (CMI) response to different antigens was examined in healthy women, in patients with cervical precancerous lesions, and in patients with cervical cancer. Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from punch biopsy material by histology. CMI response is related to specific processes in healthy and cancer cells. CMI was investigated by leukocyte adherence inhibition (LAI) assay using specific antigen (prepared from cervical carcinoma tissue) and non specific antigen (prepared from blood of mice infected by LDHlactate dehydrogenasevirus). The CMI responses of healthy women and cancer patients to the antigens used are different: the majority of T lymphocytes display adherence and non adherence, respectively (but the CMI responses elicited by the antigens are not equal and small quantitative differences are observed).
    Permanent Link: http://hdl.handle.net/11104/0184234

     
     
Number of the records: 1  

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