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Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells
- 1.0341089 - BFÚ 2010 RIV US eng J - Journal Article
Čajánek, L. - Ribeiro, D. - Liste, I. - Parish, C.L. - Bryja, Vítězslav - Arenas, E.
Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells.
Stem Cells. Roč. 27, č. 12 (2009), s. 2917-2927. ISSN 1066-5099. E-ISSN 1549-4918
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : embryonic stem cells * Wnt pathway * dopaminergic neurons
Subject RIV: BO - Biophysics
Impact factor: 7.747, year: 2009
Embryonic stem cells (ESCs) represent not only a promising source of cells for cell replacement therapy, but also a tool to study the molecular mechanisms underlying cellular signaling and dopaminergic (DA) neuron development. Here we used mouse ESCs (mESCs) lacking Wnt1 or the low-density-lipoprotein receptor-related protein 6 (LRP6) to decipher the action of Wnt/b-catenin signaling on DA neuron development in mESCs.
Permanent Link: http://hdl.handle.net/11104/0184183
Number of the records: 1