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Genetic interaction between Lrp6 and Wnt5a during mouse development
- 1.0341084 - BFÚ 2010 RIV US eng J - Journal Article
Andersson, E. - Bryjová, Lenka - Biris, K. - Yamaguchi, T.P. - Arenas, E. - Bryja, Vítězslav
Genetic interaction between Lrp6 and Wnt5a during mouse development.
Developmental Dynamics. Roč. 239, č. 1 (2010), s. 237-245. ISSN 1058-8388. E-ISSN 1097-0177
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : Wnt5a * Lrp6 * somitogenesis
Subject RIV: BO - Biophysics
Impact factor: 2.864, year: 2010
Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation.
Permanent Link: http://hdl.handle.net/11104/0184179
Number of the records: 1