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Surface plasmon resonance biosensors for detection of Alzheimer disease biomarkers
- 1.0341069 - ÚFE 2010 RIV CH eng J - Journal Article
Hegnerová, Kateřina - Bocková, Markéta - Vaisocherová, Hana - Krištofíková, Z. - Říčný, J. - Řípová, D. - Homola, Jiří
Surface plasmon resonance biosensors for detection of Alzheimer disease biomarkers.
Sensors and Actuators B - Chemical. Roč. 139, č. 1 (2009), s. 69-73. E-ISSN 0925-4005
R&D Projects: GA MZd NR9322; GA AV ČR KAN200670701
Institutional research plan: CEZ:AV0Z20670512
Keywords : Alzheimer disease * SPR sensor * 17beta-HSD10
Subject RIV: JB - Sensors, Measurment, Regulation
Impact factor: 3.083, year: 2009
This paper describes direct label-free detection of 17beta-HSD10 enzyme using a surface plasmon resonance (SPR) biosensor. This multifunctional mitochondrial enzyme is involved in pathogenesis of Alzheimer disease (AD) and represents a potential target for AD diagnostics. It is demonstrated that the reported SPR biosensor is capable of detecting 17beta-HSD10 enzyme at ng/ml levels.
Permanent Link: http://hdl.handle.net/11104/0184171
Number of the records: 1