Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis

0341047 - ÚFE 2010 RIV GB eng J - Journal Article
Krištofíková, Z. - Bocková, Markéta - Hegnerová, Kateřina - Bartoš, A. - Klaschka, J. - Říčný, J. - Řípová, D. - Homola, Jiří
Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis.
Molecular BioSystems. Roč. 10, č. 5 (2009), s. 1174-1179. ISSN 1742-206X
R&D Projects: GA MZd NR9322
Institutional research plan: CEZ:AV0Z20670512
Keywords : 17beta-HSD 10 * Alzheimer disease * SPR sensor
Subject RIV: JB - Sensors, Measurment, Regulation
Impact factor: 4.015, year: 2009

This paper describes detection of mitochondrial 17-HSD10 enzyme using a surface plasmon resonance (SPR) biosensor and ELISA method. 17-HSD10 enzyme is involved in pathogenesis of Alzheimer disease (AD) and represents a potential target for AD diagnostics. It was demonstrated that the reported SPR biosensor is capable of detecting 17β-HSD10/Aβs complex in CSF samples and it was revealed the patients with AD exhibited elavated levels of 17β-HSD10/Aβs complex compared to the controls.
Permanent Link: http://hdl.handle.net/11104/0184156