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Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: Efficacy, safety and immunomodulating activity in murine model
- 1.0340865 - MBÚ 2010 RIV US eng J - Journal Article
Šírová, Milada - Mrkvan, Tomáš - Etrych, Tomáš - Chytil, Petr - Rossmann, Pavel - Ibrahimová, Markéta - Kovář, Lubomír - Ulbrich, Karel - Říhová, Blanka
Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: Efficacy, safety and immunomodulating activity in murine model.
Pharmaceutical Research. Roč. 27, č. 1 (2010), s. 200-208. ISSN 0724-8741. E-ISSN 1573-904X
R&D Projects: GA AV ČR KAN200200651
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z40500505
Keywords : immunomodulation * doxorubicin * murine lymphoma
Subject RIV: EC - Immunology
Impact factor: 4.456, year: 2010
Well-defined linear conjugates of HPMA copolymer and doxorubicin bound via a pH-controlled linkage can induce complete cure of already developed murine solid tumors without significant side effects, and induce development of specific anti-tumor resistance. The HPMA-doxorubicin conjugate is a good candidate for clinical trials
Permanent Link: http://hdl.handle.net/11104/0005783
Number of the records: 1