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Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides
- 1.0340845 - MBÚ 2010 RIV GB eng J - Journal Article
Ulrych, Aleš - Derrick, P.J. - Adámek, F. - Novák, Petr - Lemr, Karel - Havlíček, Vladimír
Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides.
European Journal of Mass Spectrometry. Roč. 16, č. 1 (2010), s. 73-80. ISSN 1469-0667
R&D Projects: GA MŠMT LC07017
Institutional research plan: CEZ:AV0Z50200510
Keywords : antibiotics * nystatin * amphotericin
Subject RIV: EE - Microbiology, Virology
Impact factor: 1.103, year: 2010
Tandem mass spectrometry combined with Fourier transform ion cyclotron resonance (FTICR) has been the basis for rationalizing the fragmentation mechanisms of antifungal macrolides nystatin A1, amphotericin B and pimaricin. The positive ion mass spectra were not informative, however, the dissociation of deprotonated molecules led to structurally significant ring-opened fragments. Using this approach of tandem FTICR mass spectrometry (MS/MS) and electrospray ionization (ESI) coupled with high-performance liquid chromatography (HPLC), eleven macrolide natural analogues or degradation products were characterized in the nystatin mixture
Permanent Link: http://hdl.handle.net/11104/0005782
Number of the records: 1